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Department of Histology

Faculty of Medicine

TEACHING: Courses conducted

I.The basis characterization of cancer – cell behavior – uncontrolled cell proliferation – carcinoma in situ – steps in the process of metastasis – diagnosis of cancer – cancer therapy

II.Carcinogenesis – changes in the control of the cell cycle – the role of cell cycle checkpoints – cyclin-Cdk complexes of the cell-cycle control system – rB protein (retinoblastoma) – control of S phase entry – the p53 protein – tumor suppressor – the cyclin-dependent kinase (cdk) inhibitors p27, p21, and p16- oncogenesangiogenesis/ neoangiogenesis

III.Cell cultures as methods of investigating cancer biology, cytodiagnostics. – cancer cell lines – metods and usage of cell cultures – targeted anticancer therapy – viruses and carcinogenesis – cervical carcinoma cytodiagnostics

IV.Mechanisms of metastasis – Types of cell Adhesion Molecules based on interaction of thrombocyte and leukocytes with endothelial cells – cancer cell invasiveness as a key to metastasis, collagenase secretion – infiltration of blood and lymph vessels by cancer cells – infiltration of periferal organs by cancer cells – characteristics of secondary tumor growth – therapeutic implication (antiintegrins), antibody therapy etc. – tumor vascularisation

V.Histological classification of cancer – basic classification of cancer – histological slides of dysplasia, carcinoma in situ and invasive carcinoma – diagnostic immunohistochemistry markers

Site update: 07.01.2020
Zbigniew Kmieć, Iwona Pakulska