In the Laboratory of Tissue Engineering and Regenerative Medicine at the Department of Embryology at the Medical University of Gdańsk, research on new biologically active compounds, biomaterials and stem cells, as well as experimental and clinical immunology are carried out.
Tissue engineering is a relatively new branch of science based on biotechnology, molecular biology, nanotechnology and related sciences. The tissue engineering triad includes three main elements: cells, scaffolds and growth factors. Finding an appropriate combination of these elements enables the creation of an advanced medicinal product for a number of clinical applications. Thanks to its translational nature, tissue engineering constitutes the basis of regenerative and personalized medicine today.
The Laboratory Team:
Michał Pikuła MSc, MPharm, PhD (PI)
Anna Wardowska MSc, PhD
Milena Deptuła MSc, PhD
Our research currently focuses on stem cells (mainly skin and adipose-derived stem cells), biologically active peptides (pro-regenerative and immunoregulatory) and epigenetic mechanisms of the regeneration and activity of the immune system.
Grant founded by National Centre for Research and Development “New generation bioactive molecules delivery systems, based on chemically synthesised and obtained through genetic engineering nanobiomaterials” . Leader of Work Package WP9 – Michał Pikuła, PhD. Consortium Bionanova: University of Gdańsk, Medical University of Gdansk, Gdansk University of Technology, Innovabion company. Project within the programme: Modern materials technologies – TECHMATSTRATEGII (2019-2021).
Project within the Operational Programme: Intelligent Development 2014-2020 (Activity 4.4): Incubator of Innovation+ programme of the Ministry of Science and Higher Education, grant “New antibacterial peptidomimetics as potential drugs stimulating infected wound healing” (ID: 2.0/1/2019). Project in cooperation with the Faculty of Chemistry, the University of Gdansk (duration 2019-2020). Principal Investigator: Michał Pikuła, PhD.
Grant founded by the Foundation for Polish Science (FNP) „Keratinocyte-derived exosomes in the induction of allergy and tolerance to environmental allergens” (TEAM/2016-2/1, 2017 – 2019) in cooperation with University of Gdansk (leader) and Weatherall Institute of Molecular Medicine, University of Oxford.
Research project founded by the Polish National Science Center (NCN) “Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy”, grant No. 2017/26/D/ST5/00919, (2018-2021) in cooperation with University of Gdansk (leader).
• Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland
• Department of Clinical Anatomy, Medical University of Gdansk, Poland
• Department of Plastic Surgery, Medical University of Gdansk, Poland
• Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland
• Laboratory for Regenerative Biotechnology, Gdansk University of Technology, Gdansk, Poland
• Department of Molecular Biotechnology, University of Gdansk, Gdansk, Poland
• Department of Biomedicinal Chemistry, University of Gdansk, Gdansk, Poland
• Department of Biochemistry, University of Gdansk, Gdansk, Poland
• Laboratory of Neurobiology, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland
• Department of Clinical Chemistry, Lund University
• Heﬂin Center for Genomic Sciences, University of Alabama at Birmingham, Birmingham, Alabama
• Weatherall Institute of Molecular Medicine, University of Oxford
Mater Sci Eng C Mater Biol Appl. 2020 A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
EBioMedicine. 2019 Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse.
Front Immunol. 2019 Transcriptomic and Epigenetic Alterations in Dendritic Cells Correspond With Chronic Kidney Disease in Lupus Nephritis
Adv Dermatol Allergol 2019 Wound healing complications in oncological patients: perspectives for cellular therapy
Immunol Invest. 2019 Changing microRNA Expression during Three-Month Wasp Venom Immunotherapy.
Int J Mol Sci. 2019 Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus.
Adv Med Sci. 2019 Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion.
Neurochem Int. 2018 CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients.
Sci Rep. 2018 Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells.
Molecules. 2018 Antibacterial Peptides in Dermatology-Strategies for Evaluation of Allergic Potential.
J Dermatol Sci. 2018 Transcriptional profile of in vitro expanded human epidermal progenitor cells for the treatment of non-healing wounds.
Postepy Hig Med Dosw 2018 Adipose-derived stem cells for tissue engineering and therapy of non-healing wounds.
Elective courses for students (2019/2020):
Tissue engineering and personalized medicine (WL, PL, ED, 3-5 y.)
Cell therapies in regenerative medicine (WL, PL, ED, 3-5 y.)
Courses cover both practical and theoretical aspects of modern medicine, clinical immunology and biotechnology.
Michał Pikuła, MSc, PhD
Deputy Director of the First MUG Doctoral School
Laboratory of Tissue Engineering and Regenerative Medicine
Department of Embryology, Faculty of Medicine
Medical University of Gdansk (MUG)
80-210 Gdansk, Poland
Tel. 0048 58 3491368