ONGOING RESEARCH PROJECTS

Research conducted at the Department of Pharmaceutical Chemistry covers medicinal chemistry, pharmaceutical and biomedical analysis, proteomics, chemometrics, as well as issues related to bioavailability and stereoisomer analysis. The work carried out combines the development of modern analytical methods with studies on the properties, activity, and metabolism of biologically active compounds.

SELECTED PROJECTS

Antibiotics in an innovative eye drop formulation – guaranteed stability and prolonged action
Project duration: 1 October 2024–30 April 2026

MAIN RESEARCH AREAS

Medicinal chemistry
Research focuses on the mechanisms of drug action, molecular modeling, and quantitative structure–activity relationships (QSAR). These studies support the design and evaluation of the biological properties of new compounds.

Pharmaceutical analysis
Research is carried out using high-performance liquid chromatography (HPLC), liquid chromatography coupled with mass spectrometry (HPLC-MS), micellar liquid chromatography (MLC), and thin-layer chromatography (TLC). It also includes the development, validation, and optimization of analytical methods, as well as studies on quantitative structure–retention relationships (QSRR).

Proteomics and comparative studies
Research includes protein identification using chemometric techniques, comparative analyses, and the assessment of the metabolic stability of compounds of pharmaceutical relevance.

Chemometrics and biostatistics
Advanced statistical and chemometric tools such as MLR, PCA, PLS, and FA are used in data analysis. These methods enable the interpretation of complex analytical data and the modeling of relationships between the structure, properties, and activity of the studied compounds.

Drug bioavailability
Research is conducted on factors affecting the biological availability of medicinal substances and their application potential.

Stereoisomer analysis
Research includes the qualitative and quantitative analysis of stereoisomers, which is important from the perspective of biological activity, safety, and quality control of pharmaceutical substances.

Electromigration techniques in pharmaceutical analysis
The research employs capillary electrophoresis (CE), electrochromatography (EC), and gel electrophoresis (GE) in the analysis of drugs and endogenous substances.

INFORMATION FOR STUDENTS INTERESTED IN A MASTER’S THESIS

The Department and Pharmaceutical Chemistry at the Medical University of Gdańsk informs that the primary criterion for selecting candidates for Master’s theses carried out in our unit is the grade obtained in the Medicinal Chemistry examination.

Additional advantages may include:

active participation in the Student Research Club at the Department of Pharmaceutical Chemistry,
good grades in the following subjects: Biochemistry and Analytical Chemistry.

Active participation in the Student Research Club at the Department of Pharmaceutical Chemistry is usually associated with involvement in research work conducted at the Department.