In the Department of Physiopathology, research projects are carried out as part of the statutory activity (entitled “The role of limited proteolytic processes in the aging of lymphocytes and pathogenesis of chronic inflammatory and neurodegenerative diseases”) and individual projects funded by the Ministry of Science and Higher Education and the National Science Center.

Grants won:

• Grant of the National Science Center Miniatura 8 points. “Molecular basis of the effect of black cumin seed essential oil on T lymphocytes.” Project leader Dr. Klaudia Ciesielska-Figlon
• National Science Center project Opus 22“Novel immunomodulators of the BTLA-HVEM complex as a potential therapy in systemic lupus erythematosus” (PI: dr. hab. Anna Wardowska, 2022-2026)
• Scientific grant of the Polpharma Foundation “The immune system of patients with the renal form of systemic lupus erythematosus after infection with SARS-CoV-2” (PI: dr. hab. Anna Wardowska, 2021-2024)
• National Science Center project Miniatura 2 “Interplay of apoptosis and autophagy of peripheral blood T lymphocytes in depressive disorders” (PI: dr. Krzysztof Pietruczuk, 2019)
• National Science Center project UMO-2011/01/M/NZ3/02948 “Possible participation of changes in the activity of the calpain-calpastatin system in the aging processes of human T lymphocytes – a comparison of long-lived people of Poland (Pomerania) and Italy (Sicily)” (PI: prof. dr hab. Jacek M. Witkowski, 2012-2014)
• Scientific Research Committee project N N401 614140 “Effect of normothymic drugs on apoptosis and activation of peripheral blood T cells in patients with bipolar disorder” (PI: dr. Krzysztof Pietruczuk, 2012-2013)
• Ministry of Science and Higher Education project Iuventus Plus IP2010 022770 “Regulation of transcription of the gene encoding the erythropoietin receptor in CD4 + T cells” (PI: dr. Katarzyna Lisowska, 2011)
• Ministry of Science and Higher Education project Iuventus Plus IP2010 038770 “The effect of inhibition of ZNF334 expression on the phenotype and function of CD4+ lymphocytes from people with rheumatoid arthritis and an attempt to investigate the molecular basis of this phenomenon” (PI: dr. Monika Soroczyńska-Cybula, 2011)

Own research:

• MB No. 01-65024/262: The role of HMGB1, RANKL proteins and Toll-like receptors in
  pathogenesis of rheumatoid arthritis (doctoral dissertation, supervisor work: Aleksandra Korzeniowska)
• IDUB 01-0502/08/262: Lysoproteomic analysis of the products of the action of calpain proteases in human immune cells (PI: prof. dr hab. Jacek Witkowski, 2021)
• IDUB 01-0510/08/262: Evaluation of α-Klotho expression in CD4+ T cells in hemodialysis patients (PI: dr. hab. Katarzyna Lisowska, 2021)
• MB 01-0422/08/262: Impact assessment of two non-invasive methods of vagus nerve stimulation on the mental state and selected parameters of the immune system of patients suffering from unipolar depression (doctoral dissertation, PI: Mateusz Maziewski)
• MB 01-423/08/262: The influence of ketamine on immune system in patients with depression (doctoral dissertation, PI: Łukasz Szałach)
• MB 01-0422/08/262: Influence of black cumin oil (Nigella sativa) on phenotype, activations, and apoptosis of T lymphocytes (doctoral dissertation, PI: Klaudia Ciesielska-Figlon)
• MN 01-0113/08: The role of microRNA in the aging process of human T lymphocytes (doctoral dissertation, PI: Joanna Frąckowiak)
• MN 101: Assessment of B lymphocyte function in patients with chronic kidney disease and its modulation by erythropoietin (doctoral dissertation, PI: Aleksandra Jasiulewicz)