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Department of Pharmaceutical Pathophysiology

Faculty of Pharmacy

EMPLOYEES

Head:

Prof. Dr. Habil. Iwona Inkielewicz-Stępniak

Prof. Dr. Habil. Iwona Inkielewicz-Stępniak

E-mail:iwona.inkielewicz-stepniak@gumed.edu.pl
Direct number:58 349 15 16 ext. 1516

I am a graduate of the MUG (Faculty of Pharmacy). I completed two post-doc research internships at Trinity College Dublin, where I was involved in researching the pharmacological activity of new aspirin analogues as well as nanopharmacology and nanotoxicology in vitro. My research interests are focused on experimental nanomedicine, platelet pharmacology, research on the interaction of platelets with neoplastic cells and the role of platelets in the formation of neoplastic metastases, and research on the development of targeted therapy for pancreatic cancer. Currently, I am Principal Investigator of two grant projects financed by the National Science Center: OPUS (evaluation of the potential antitumor activity of new opioid growth factor analogues in the treatment of pancreatic cancer), HARMONIA (evaluation of the anticoagulant and antiplatelet activity of functionalized silver nanoparticles) and a PI at MUG of EU-funded Research and Innovation Programme Horizon: PRECODE (development of a three-dimensional model of pancreatic cancer). I am also a research supervisor in three PRELUDIUM grants and two intra-university Young Creator of Science grants. I cooperate with Trinity College Dublin, Erlangen Clinical University and the University of Saskatchewan. I am the supervisor of five completed doctorates and four currently being pursued.

Associate Professors:

Dr. Habil. Barbara Lewko, Assoc. Prof.

E-mail:barbara.lewko@gumed.edu.pl
Direct number:58 349 21 86 ext. 2186

The scope of the research performed in the Laboratory of Experimental Nephrology includes the in vitro studies on podocytes, the cells of the renal glomerulus. Currently, the interest is focused on • Effects of the polyphenolic compounds, urolithins on the mechanisms regulating podocyte functions • Impact of the high glucose milieu on podocyte functions and structure.

Assistant Professors:

Damian Flis, Ph.D.

Damian Flis, Ph.D.

E-mail:damian.flis@gumed.edu.pl
Direct number:58 349 15 17 ext. 1517

Assistant professor at the Department of Pharmaceutical Pathophysiology. The topic of his doctoral dissertation was the influence of swimming on the concentration of mitochondrial cholesterol and energy metabolism in conditions of oxidative stress. The main scientific interests of the doctor include research on energy and free radical metabolism and mitochondrial function in conditions of health, physical exercise, and pathology development. At present, Mr. Damian works on scientific projects related to the search of the mechanism responsible for changes in the mitochondrial cholesterol level under exercise condition- the role of Caveolin-1 protein, and molecular mechanism of the protective effect of swimming training on skeletal muscle atrophy and the course of amyotrophic lateral sclerosis (ALS).

Szymon Kowalski, Ph.D.

Szymon Kowalski, Ph.D.

E-mail:szymon.kowalski@gumed.edu.pl
Direct number:58 349 15 17 ext. 1517

Dr Szymon Kowalski is a graduate in Biotechnology of the Faculty of Chemistry of the University of Technology in Gdansk. Under the direction of prof. Iwona Inkielewicz-Stępniak, he finished with distinction his doctoral dissertation in 2020, entitled “Molecular mechanism of cytotoxic activity newly synthesized oxidovanadium(IV) complexes in pancreatic ductal adenocarcinoma cell line”. In 2018, he did 3 months’ internship at Universitätsklinikum Erlangen in Germany, analysing migration ability of pancreatic cancer cells by using CRISPR/Cas9 technique. Currently, he is researcher in European grant PRECODE, where he is developing new pancreatic cancer in vitro model: organoids and their interaction with platelets. Moreover, he participates in other research projects: MINIATURA 5 and OPUS 18. Scientific interests of Doctor Szymon Kowalski relate to molecular and cellular pharmacology as well as cancer biology, especially pancreatic cancer and the role of the peripheral nervous system in its progression.

Senior Specialists:

Shaoshan Mai, MPharm.

Shaoshan Mai, MPharm.

E-mail:shaoshan.mai@gumed.edu.pl
Direct number:58 349 15 17

I did some research on stem cells and autoimmune disease during my study of Master degree in China. After graduation, I worked as a research assistant to investigate lung cancer, hepatic cancer and pancreatic cancer in Sun Yan-sen University. In 2018, I moved to Germany and worked with gastric cancer induced by helicobacter pylori(H. pylori) infection. Currently, I am an ESR in EU Horizon 2020 Marie Skłodowska-Curie Program(PancREatic Cancer OrganoiDs rEsearch, PRECODE) under the supervision of Prof. Iwona Inkielewicz-Stępniak. I cooperate with colleagues in our lab to develop three-dimensional model of pancreatic cancer ( Patient-Derived Organoids ), set up co-culture system in organoids with platelets, organoids with human umbilical vein endothelial cells(HUVECs). To investigate the crosstalk between platelets or HUVECs and organoids, and effect of chemical drugs, nanoparticle drugs on pancreatic cancer treatment are part of my PhD study project. My scientific interests are tumor treatment, autoimmune disease and nanoparticle medicines.

Specialists:

Elżbieta Latawiec

E-mail:elzbieta.latawiec@gumed.edu.pl
Direct number:58 349 15 17 ext. 1517

Doctoral Students:

Justyna Budka, M.A.

Justyna Budka, M.A.

E-mail:justyna.budka@gumed.edu.pl
Direct number:58 349 15 17

I am a graduate of the Faculty of Biology and the Faculty of Chemistry at the University of Gdańsk. The subject of my interest is the problem of cancer, in particular pancreatic cancer. In the oncological therapy of the pancreas, chemotherapeutic agents that would be highly effective in reducing tumor mass and show a selective effect are still being sought. As part of my doctoral dissertation, I synthesize compounds with potential antitumor activity and determine their impact on pancreatic cancer cells in vitro.

Damian Drążewski, M.D.

Damian Drążewski, M.D.

E-mail:damian.stom@gmail.com

I am a graduate of the Faculty of Medicine at the Medical University of Poznań. My research interests focus on the molecular mechanisms related to the aging process of the skin and the use of tissue stimulants in anti-aging treatments. The second area of my research is to determine how collagen stimulators work at the cellular level and to assess their impact on protection against the harmful effects of UV radiation on skin cells.

Justyna Hajtuch, M.A.

Justyna Hajtuch, M.A.

E-mail:justyna.hajtuch@gumed.edu.pl
Direct number:58 349 15 17

I am a graduate of biotechnology and a pharmaceutical technician. My research interests are focused on nanomedicine. In the ongoing projects, I am assessing the potential application of nanoparticles in diseases related to the hemostatic system. These studies consider the antiplatelet activity of functionalized silver nanoparticles and their use as a drug delivery system or as a coating material for medical devices.

Milena Kotewicz, M.A.

Milena Kotewicz, M.A.

E-mail:mkotewicz@gumed.edu.pl
Direct number:58 349 15 17

Laboratory diagnostician by profession, scientist by choice. I conduct experiments in the field of experimental nephrology, studying the influence of polyphenolic derivatives on the structure and functions of podocytes. In the times of diabetes epidemic around the world, I am trying to find a natural alternative in protecting the diabetic kidney.

Aleksandra Marchwińska, M. Eng.

Direct number:58 349 15 17

Swathy Krishna Reghukumar, MPharm.

Swathy Krishna Reghukumar, MPharm.

E-mail:swathy.reghukmar@gumed.edu.pl

I graduated in Pharmacology from JSS Academy of Higher Education and Research (Mysore, India). My current research topic under the supervision of Prof. Dr. Iwona Inkielewicz-Stępniak and prof. Elzbiety Megiel from Warsaw University involves evaluation of anti-cancer activity of novel functionalized metal nanoparticles in breast cancer therapy. This involves the synthesis of functionalized metal nanoparticles and evaluation of their potential for selective cytotoxic action against cancer cells.

Karol Steckiewicz, Ph.D.

Karol Steckiewicz, Ph.D.

E-mail:karol.steckiewicz@gumed.edu.pl

My scientific interests focus on nanotechnology with particular emphasis on research in the field of nanomedicine. In the current projects, we are focusing on assessing the role of noble metal nanoparticles as drug carriers that can potentially be used in periodontitis and inflammatory bowel diseases. We study the anti-inflammatory and antimicrobial properties of nanoparticles as well as the synergistic effects of nanoparticles and drugs. My clinical interests focus on anaesthesiology and intensive care

Anna Szczoczarz, M.A.

Anna Szczoczarz, M.A.

E-mail:anna.szczoczarz@gumed.edu.pl
Direct number:58 349 15 17

I am a graduate of Medical Analytics at the Medical University of Gdańsk. My research interests include in vivo research, mechanisms and regulation of insulin secretion, metabolic syndrome, insulin resistance, lipodystrophy, type II diabetes.

Site update: 03.04.2022
Justyna Budka, Justyna Hajtuch, Iwona Inkielewicz-Stępniak, Artur Lehmann